List of Aromatase inhibitors

Once the medication is selected, your oncologist will determine the appropriate dosage. The dosage may vary depending on individual factors and may be adjusted throughout the course of treatment. It is important to follow your oncologist’s instructions regarding dosage to ensure optimal effectiveness. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Side Effects of Aromatase Inhibitors

For example, the use of vaginal lubricants, moisturizers, and vaginal massage with coconut oil are some examples of treatments that may benefit women who experience vaginal dryness or pain (Lee et al., 2011). A referral to a pelvic physical therapist https://www.pizzaislandstorget.se/how-steroids-improve-power-output-in-weight/ can be valuable and complement symptom management. If the above are not effective, low-dose vaginal estrogen is currently recommended. Recent practice recommendations deem low-dose vaginal estrogen as safe to use (American College of Obstetricians and Gynecologists, 2018; Melisko et al., 2017).

AIs may also increase cholesterol, especially in women with pre-existing heart disease, increasing the risk of heart problems. Statins could be used along with AIs to improve both lipid profiles and endothelial function. There is also a suggestion that long-term use of a lipophilic statin might reduce breast cancer risk (76), but results in case–control studies are mixed (77–79). However, because both statins and AIs are metabolised in the liver, pharmacological and pharmacodynamical studies need to be completed to better understand how concomitant administration might affect levels of both drugs. As anagent to induce ovulation, dosing is 2.5 mg to 5 mg daily for 5 days starting on day 3 of the menstrual cycle. In patients with cirrhosis of the liver, CHild-Pugh Class C, increase the dosing interval to every 48 hours.

Women on aromatase inhibitors are at a two- and four-fold increased risk of bone loss compared to a matched set of women in the general population, says a 2015 review in the Journal of Bone Oncology. The long-term effects of aromatase inhibitors are arguably more concerning. Unlike tamoxifen, aromatase inhibitors tend to speed up osteopenia (bone loss) in older women who are already at risk of bone problems. As with any medication, aromatase inhibitors can cause side effects and adverse reactions. Some of the more common ones are related to the reduction of estrogen in the body, leading to menopausal symptoms and other more potentially serious complications.

Although pathological complete response rates after neoadjuvant chemotherapy are in the 20% or higher range for hormone receptor-negative tumours, they are rare with tumours that are hormone receptor-positive. Exesin 25mg Tablet is an anticancer drug with the active ingredient Exemestane. In postmenopausal women, it is used to treat hormone-dependent early breast cancer after completing 2-3 years of treatment with Tamoxifen. Cancer is a disorder in which cells multiply in an uncontrolled and abnormal manner.

Adjusted hazard ratios (HR) for subsequent breast cancer and 95% confidence intervals (CI) were estimated using Cox proportional hazards models with time-dependent drug use status. Hence, the person-time accrual began on the date of the hormonal treatment initiation 22. It is approved for the treatment of estrogen receptor-positive breast cancer in postmenopausal women. This medication comprises exemestane (an antineoplastic aromatase inhibitor). In some cases, it is also used as an adjuvant treatment for breast cancer.

Completing Aromatase Inhibitor Therapy

Based on the current literature, it is not advisable to use red wine as a chemopreventive agent or a cancer-fighting nutritional supplement, but there is sufficient evidence to investigate it further concerning its ability to inhibit the aromatase enzyme. Patients react differently to aromatase inhibitors, but few experience side effects severe enough to interfere with daily life. Exemestane is a generic drug that is available in a brand-name form called Aromasin. A generic drug is an exact copy of the active drug in a brand-name medication.

Unravelling the mechanisms responsible for the superiority of AIs is not only of interest biologically but it may also be help to achieve further improvements in endocrine therapy in the future. Most endocrine therapies for breast cancer treatment and prevention depend upon inhibiting the proliferative effect of oestradiol on oestrogen receptor (ER)-positive tumour or normal mammary epithelial cells. Either oestradiol is inhibited from binding to ER by antioestrogens, or serum and tissue oestradiol concentrations are reduced by ovarian ablation in premenopausal women or by inhibition of aromatase in postmenopausal women.

• Pre- to post-intervention changes in breast tumor markers of proliferation (Ki-67), apoptosis (caspase), and the hormone receptor ERβ were assessed with immunohistochemistry.
• Clinical trials found TAM decreases the risk of subsequent breast cancer by 50% 12.
• Many of the formulations we use in our therapies are not covered by insurance, and the cost of overall treatment is often less than when using insurance.
• In conclusion, the treatment process of aromatase inhibitor therapy involves medication selection, dosage determination, and regular follow-up appointments.
• Therefore, Magicine Pharma isn’t responsible for the content of the links in the website or links in the linked websites.
• According to a 2015 study in The Lancet, aromatase inhibitors are 30% more effective in preventing breast cancer recurrence and are able to decrease mortality rates by 15% after five years when compared to tamoxifen.

Causes & Risk Factors

After primary treatment for breast cancer, there is a risk of recurrence, when the cancer is in remission (no detectable cancer) and then comes back. Exemestane is a member of the aromatase inhibitors drug class and is commonly used for Breast Cancer. If you have vaginal dryness or other vaginal symptoms, talk with your health care provider about ways to treat them.